I split my weekly dose in half for six weeks to see whether it smoothed the first two days out, and the result was less impressive than I expected.
The narrow version of the question is what the pharmacokinetic argument against splitting a weekly dose actually is, since intuitively it should smooth the curve.
Practical detail welcome, however dull — the duller the better.
DanielChem_CHI said:I split my weekly dose in half for six weeks to see whether it smoothed the first two days out, and the result was less impressive than I expected.
Dose splitting update on split dosing: instead of 2.4mg once weekly, I've been doing 1.2mg twice weekly (Mon/Thu) with my doctor's approval. The appetite suppression is more consistent and side effects are noticeably milder.
Not medical advice, just sharing what's worked for me. Discuss with your provider before trying this.
NeuroNate said:Dose splitting update on split dosing: instead of 2.4mg once weekly, I've been doing 1.2mg twice weekly (Mon/Thu) with my doctor's approval.
Right, and the exception is worth naming rather than left implied, because the exception is where people get into trouble.
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Shop Reference StandardsDanielChem_CHI said:I split my weekly dose in half for six weeks to see whether it smoothed the first two days out, and the result was less impressive than I expected.
Second this.
Adding the clinical framing, because it changes how the question reads. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.