From the other side of the consultation, briefly. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
PharmacoVig_BOS said:Say what you would expect to see if you were wrong, before you look.
This is exactly what I could not find anywhere else. Sending this to two other people who asked me the same thing last week.
Adding the clinical framing, because it changes how the question reads. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.
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Browse GL BiochemDr.PeteFamMed said:If two explanations both fit, the useful question is which one predicts something the other does not.
Second this. Posting only so the count is not one.