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Forums›Metabolic Health & Diabetes›Adiponectin and leptin changes on GLP-1 therapy — 12 month update › Page 2

Adiponectin and leptin changes on GLP-1 therapy — 12 month update

Dr.PathRoch Sun, Oct 6, 2024 at 8:34 PM 12 replies 1,878 viewsPage 2 of 3
SleepDoc_PDX
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Sep 2024
Portland, OR
Oct 7, 2024 at 7:25 AM#6
The mental-health dimension is under-measured in the trial literature and the reports here are consistent enough to take seriously.
...mental health should only be used alongside therapy...

I'd say therapy should be AVAILABLE to all GLP-1 patients, but requiring it as a precondition for treatment would create an access barrier.

Not everyone can afford therapy. Not everyone needs it. Some people do just fine with medication + lifestyle changes. But for those with emotional eating, body image issues, or disordered eating history, therapy is extremely valuable.

My recommendation: make mental health screening part of the initial assessment, offer therapy as a recommended adjunct, but don't gatekeep medication access behind it.

16 11pete_nash, hank_denver, carlos_SATX and 13 others
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DerekSJ_a1c
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Aug 2024
San Jose, CA
Oct 7, 2024 at 11:41 AM#7

One thing that is still open after TrialTracker_MD’s answer:

What did you change at the same time, and can you separate the two now?

15 10Dr.SurgeonPGH, rachel_ABQ, traveltech_sara and 12 others
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chris_chi24
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1,678
Sep 2024
Chicago, IL
Oct 7, 2024 at 3:57 PM#8
Dr.PathRoch said: ...mental health should only be used alongside therapy...

Positive side effects of mental health that surprised me:

  1. Clearer skin — inflammation reduction improved my rosacea
  2. Better sleep — weight loss resolved mild sleep apnea
  3. Improved libido — better body image + improved cardiovascular health
  4. Less joint pain — obvious mechanical benefit
  5. More energy — metabolic improvements across the board

Not everything about GLP-1 therapy is a struggle. There are genuinely wonderful changes too. ✨

14 9MaxMetOK, MounjBrad, nick_newbie and 11 others
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Dr.PathRoch
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Jun 2024
Rochester, MN
Oct 7, 2024 at 8:13 PM#9

Closing the loop on my own question.

Follow-up — I put something in the gap where food used to be rather than waiting for the gap to close on its own. That was the part nobody told me.

Last edited: Oct 8, 2024 at 2:13 AM
13 8SaraMom3, Dr.MetabolicMD, RetaRick_CA and 10 others
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JakeBK_lifts
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Jul 2024
Brooklyn, NY
Oct 8, 2024 at 4:42 PM#10
Positive side effects of mental health that surprised me: Clearer skin — inflammation reduction improved my rosacea Better sleep — weight loss…

When to call your doctor about mental health side effects — a reference I wish I'd had:

Call immediately:

  • Severe abdominal pain (could be pancreatitis)
  • Vision changes (thyroid concern)
  • Lump in neck (thyroid nodule)
  • Severe vomiting/can't keep fluids down for 24h+

Schedule an appointment:

  • Persistent nausea beyond 4 weeks
  • Significant hair loss
  • Mood changes or depression
  • Gallbladder symptoms (RUQ pain after eating)
27 2DataDave, Dr.GutHealth, amsterdam_pete and 24 others
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