andrew_nyc said:Dr.MetabolicMD said: ...regarding food noise mechanism of action...
Central vs peripheral GLP-1R signaling in food noise: elegant studies using brain-penetrant vs peripherally-restricted GLP-1 agonists show that ~80% of the weight loss effect is centrally mediated[1].
The key brain regions: arcuate nucleus (appetite), area postrema (nausea), NTS (satiety), VTA/NAc (reward). Peripheral effects (gastric emptying, insulin secretion) contribute but are secondary for weight loss.
This has implications for next-gen drugs: optimizing brain penetration and CNS receptor occupancy may be more important than systemic exposure.
[1] Secher A, et al. J Clin Invest. 2014;124(10):4473-4488.
RickReta_CO said:Phantom hunger vs real hunger on food noise: learning to distinguish between the two has been a revelation.
Saving this. It is the first explanation that did not require me to already understand it. Printing the relevant bit and taking it with me.
andrew_nyc said:Dr.MetabolicMD said: ...regarding food noise mechanism of action...
I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.
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