Dr.SurgeonPGH said:It helps to say which part of this you are uncertain about.
All true, with one condition: that curve is for people who reached the dose on schedule. Anyone who slowed the ladder for tolerability is on a different, flatter curve, and comparing yourself with the published mean will make you feel like a non-responder when you are not.
TirzTom said:Steady state is the thing most people miss.
Thank you for spelling out the reasoning rather than just the conclusion. Printing the relevant bit and taking it with me.
Dr.SurgeonPGH said:It helps to say which part of this you are uncertain about.
Pushing back on Dr.SurgeonPGH here. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
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Shop Reference StandardsOne concrete data point for the thread. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.
Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. Tagging this one for the weekly digest.