Dr.AddMedPHL said:If two explanations both fit, the useful question is which one predicts something the other does not.
Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.
HPLC_Greg said:The mechanism that matters here is not stomach emptying, it is central.
Thank you for spelling out the reasoning rather than just the conclusion. Taking it to my next appointment.
Dr.AddMedPHL said:If two explanations both fit, the useful question is which one predicts something the other does not.
I will push back on the "any working dose is fine" framing. The maintenance evidence sits overwhelmingly at the top studied dose, and the extension data shows regain tracking dose reduction rather than tracking stopping. Holding low is reasonable; pretending it is evidentially equivalent is not.
I would rather be corrected than agreed with, if it comes to it.
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Ask again with the specifics and you will get a better answer than this one.