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Forums›Psychological & Behavioral›Cognitive effects of GLP-1 agonists — July 2024 › Page 2

Cognitive effects of GLP-1 agonists — July 2024

SandraNC_45 Tue, Sep 2, 2025 at 3:30 PM 12 replies 1,380 viewsPage 2 of 3
lisa_labSD
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San Diego, CA
Sep 2, 2025 at 6:14 PM#6
The mental-health dimension is under-measured in the trial literature and the reports here are consistent enough to take seriously.
...mental health should only be used alongside therapy...

I'd say therapy should be AVAILABLE to all GLP-1 patients, but requiring it as a precondition for treatment would create an access barrier.

Not everyone can afford therapy. Not everyone needs it. Some people do just fine with medication + lifestyle changes. But for those with emotional eating, body image issues, or disordered eating history, therapy is extremely valuable.

My recommendation: make mental health screening part of the initial assessment, offer therapy as a recommended adjunct, but don't gatekeep medication access behind it.

Last edited: Sep 2, 2025 at 9:14 PM
43 13stefan_berlin, Dr.EM_Chicago, pete_RVA and 40 others
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sarah_TO
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Sep 2024
Toronto, CA
Sep 2, 2025 at 7:18 PM#7

Following on from PharmacoVig_BOS — and this may be the naive question:

How would you tell the difference between that and the alternative explanation?

42 12Dr.EndoEP, GraceAZ_72, carl_compliance and 39 others
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sean_dublin
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Nov 2024
Dublin, IE
Sep 2, 2025 at 8:22 PM#8
SandraNC_45 said: ...mental health should only be used alongside therapy...

Mood changes on mental health: I want to be transparent — I went through a rough patch emotionally around month 4. Not depression exactly, but a weird flatness. Food was my main coping mechanism and without that, I had to develop new ones.

Therapy has been essential. I'd strongly recommend anyone starting GLP-1 therapy also invest in mental health support. The physical transformation is only half the journey.

41 11gary_naperville, sean_dublin, hannah_MT and 38 others
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SandraNC_45
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Sep 2024
Charlotte, NC
Sep 2, 2025 at 9:26 PM#9

Closing the loop on my own question.

Follow-up — I put something in the gap where food used to be rather than waiting for the gap to close on its own. That was the part nobody told me.

40 10mike_mealprep, NicoleRaleigh, james_edin and 37 others
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JenMemphis
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Jan 2025
Memphis, TN
Sep 3, 2025 at 2:34 AM#10
Mood changes on mental health: I want to be transparent — I went through a rough patch emotionally around month 4.

Anxiety increase on mental health: counterintuitive, but losing weight rapidly triggered anxiety for me. Change — even positive change — is stressful. I was anxious about whether I deserved to feel good.

This is more common than people admit. A therapist who specializes in weight management has been invaluable. Don't neglect the mental health side of this journey.

10 10LarryQC_SD, wanda_boise, NurseAsh_DET and 7 others
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