Dr.ObesityLA said:KevinCompounds said: ...we don't know the long-term effects of cardiovascular risk...
6 month update on cardiovascular risk: down 39 lbs, off blood pressure meds, A1C normalized. Genuinely life-changing.
GenomicsKate said:NNT calculation for cardiovascular risk clinical endpoints: NNT = 1/ARR (absolute risk reduction).
That reframing is the part I needed. Printing the relevant bit and taking it with me.
Dr.ObesityLA said:KevinCompounds said: ...we don't know the long-term effects of cardiovascular risk...
Vitamin deficiency cascade with cardiovascular risk: after 6+ months of reduced food intake, I developed a subtle but important pattern: low B12 → elevated homocysteine → increased cardiovascular risk marker.
The connection: B12 is a cofactor for homocysteine metabolism. Without adequate B12, homocysteine accumulates. This is ironic — taking a CV-protective medication while developing a CV risk factor from reduced nutrition.
Solution: comprehensive vitamin supplementation and regular lab monitoring. Don't let the medication's benefits be undermined by nutritional deficiencies.
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View ResultsMASHdoc_SA said:My reason for being on this is cardiovascular rather than cosmetic, which puts me in a small minority in most of these threads.
MASHdoc_SA said:...cardiovascular risk is just another fad...
I understand the skepticism — we've all seen "miracle" weight loss solutions come and go. But consider what makes GLP-1 agonists different:
- Phase 3 RCTs with thousands of participants (not 20-person pilot studies)
- Published in NEJM, JAMA, Lancet (not press releases)
- Replicated across multiple independent research groups
- Proven cardiovascular and renal benefits beyond weight loss
- Biological mechanism fully characterized at the receptor level
This isn't a fad — it's a new drug class supported by the highest level of clinical evidence. The comparison to past fads is understandable but inappropriate.
Moderator note: a couple of off-topic posts removed. Thread quality here is what the rules are for. Keep it up.