Kidney function on semaglutide — eGFR and UACR improvements

Adding my data. Not T2D, just obese with early CKD2. Tirzepatide 7.5 mg, 6 months: | Marker | Baseline | Month 6 | |--------|----------|---------| | eGFR | 72 mL/min | 78 mL/min | | UACR | 42 mg/g | 18 mg/g | | Creatinine | 1.08 mg/dL | 0.98 mg/dL | | Uric Acid | 8.2 mg/dL | 6.1 mg/dL | The UACR normalization is great, but I'm also really happy about the uric acid drop. Hyperuricemia is independently nephrotoxic and contributes to CKD progression. GLP-1 RAs appear to lower uric acid through increased renal excretion.

jason_sac26, great point about uric acid. It's an underappreciated marker in kidney disease. The GLP-1 effect on uric acid is partly mediated by improved insulin sensitivity (insulin promotes uric acid reabsorption in the proximal tubule) and partly by natriuresis. Your UACR going from 42 to 18 — normal is <30, so you've gone from microalbuminuria to normal range. That's clinically meaningful CKD regression.