Prescribed on cardiovascular grounds rather than for weight, and almost everything written for patients assumes the opposite.
So the question, as narrowly as I can put it: how much of the SELECT benefit is plausibly independent of the weight loss, and whether that distinction changes anything practical.
I would rather have one careful answer than five confident ones.
Dr.DermMIA said:Prescribed on cardiovascular grounds rather than for weight, and almost everything written for patients assumes the opposite.
Continuous metabolic monitoring dashboard for cardiovascular risk — I track everything in a spreadsheet and here's the month-over-month trend for my key markers:
Weight: consistent downtrend, -1.6 lbs/week average
Fasting glucose (finger stick): stable at 87 mg/dL
Blood pressure (home): 116/73 average
Resting heart rate: 67 bpm (down from 83)
Waist circumference: down 17 inches total
The resting heart rate improvement correlates with cardiovascular fitness gains. Everything is moving in the right direction.
Dr.PainCLE said:Continuous metabolic monitoring dashboard for cardiovascular risk — I track everything in a spreadsheet and here's the month-over-month trend for my…
Senior perspective on cardiovascular risk: I'm 63 years old and started this journey skeptically. My endocrinologist recommended it after years of failed interventions.
15 months later: down 41 lbs, more mobile, pain reduced, medications simplified. My quality of life has improved dramatically. I wish this existed 20 years ago.
To other older adults hesitating: the SELECT trial proved benefit in our age group. You deserve to feel good in your body regardless of age.
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View ResultsDr.DermMIA said:Prescribed on cardiovascular grounds rather than for weight, and almost everything written for patients assumes the opposite.
Adding a me-too, because a thread of one person's experience is not much use.
From the other side of the consultation, briefly.
Metabolic syndrome resolution on cardiovascular risk: I went from meeting 4 of 5 diagnostic criteria to meeting ZERO after 9 months of treatment.
The 5 criteria (and my journey):
- Waist circumference: 48" → 34" ✅ Resolved
- Triglycerides: 268 → 98 ✅ Resolved
- HDL: 32 → 60 ✅ Resolved
- Blood pressure: 148/90 → 121/75 ✅ Resolved
- Fasting glucose: 118 → 84 ✅ Resolved
Metabolic syndrome reversal is, in my view, the most medically significant outcome of GLP-1 therapy.