carl_compliance said:No disagreement, though the timescale matters more than the mechanism here.
Same pattern here, and in the same order. The detail I would add is minor and it is already implied above.
carl_compliance said:No disagreement, though the timescale matters more than the mechanism here.
Coming at carl_compliance’s question from a different direction. Relative and absolute effects need reading together. A 20% relative reduction on a high baseline risk is a large absolute benefit; the same relative figure on a low baseline risk is a small one, and press summaries almost always quote the relative number because it is bigger.
One concrete data point for the thread. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.
Worth separating that from the trial evidence, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.
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Browse GL BiochemOne thing that is still open after carl_compliance’s answer:
How to read a result like this without either dismissing it or over-reading it, since the summaries all read like press releases?
stefan_berlin said:For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.
I read this differently from stefan_berlin, on substance rather than tone. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.
I would rather be corrected than agreed with, if it comes to it.