anna.melb_AU said:Lp(a) and cardiovascular risk: a nuance that matters.
Mendelian randomization evidence supporting GLP-1 pathway modulation for cardiovascular risk: genetic variants in the GLP1R gene region associated with lower BMI also show associations with reduced cardiovascular risk, confirming a causal pathway[1].
This "natural experiment" (people born with genetically higher GLP-1 signaling being leaner and healthier) provides orthogonal evidence supporting the pharmacological approach. When genetic epidemiology, clinical trials, and mechanistic studies all converge, confidence in the therapeutic approach is high.
[1] Zheng SL, et al. Lancet Diabetes Endocrinol. 2023;11(12):869-879.
fiona_glasgow said:mike_nyc said: ...we're creating a generation dependent on cardiovascular risk...
This is exactly what I could not find anywhere else.
anna.melb_AU said:Lp(a) and cardiovascular risk: a nuance that matters.
Anti-inflammatory mechanisms of GLP-1 agonists and cardiovascular risk: beyond weight loss, GLP-1R activation directly suppresses NF-κB signaling, reduces NLRP3 inflammasome activation, and decreases monocyte/macrophage adhesion to endothelium[1].
Clinical correlates: hsCRP reduction of 30-60% (consistently seen across trials), reduced carotid intima-media thickness, and decreased coronary plaque inflammation on PET imaging.
These anti-inflammatory effects likely contribute to the cardiovascular benefit seen in SELECT — and may explain benefits beyond what weight loss alone would predict.
[1] Hogan AE, et al. Diabetologia. 2014;57(4):781-784.
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View ResultsKarenAZ_mom said:My reason for being on this is cardiovascular rather than cosmetic, which puts me in a small minority in most of these threads.
Senior perspective on cardiovascular risk: I'm 65 years old and started this journey skeptically. My endocrinologist recommended it after years of failed interventions.
11 months later: down 53 lbs, more mobile, pain reduced, medications simplified. My quality of life has improved dramatically. I wish this existed 20 years ago.
To other older adults hesitating: the SELECT trial proved benefit in our age group. You deserve to feel good in your body regardless of age.
Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Carry on.