DataDave said:The dose-response is real but shallow at the top.
I will push back on the "any working dose is fine" framing. The maintenance evidence sits overwhelmingly at the top studied dose, and the extension data shows regain tracking dose reduction rather than tracking stopping. Holding low is reasonable; pretending it is evidentially equivalent is not.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
The figures, for anyone assembling their own picture. Worth knowing that the injection site changes very little. Abdomen, thigh and upper arm are bioequivalent for semaglutide, so a site change is not a plausible explanation for a bad week.
Ask again with the specifics and you will get a better answer than this one.
DebRD_ATL said:I will push back on the "any working dose is fine" framing.
There is a second half to this that has not been said yet. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.
Ask again with the specifics and you will get a better answer than this one.
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Browse GL BiochemOne thing that is still open after GraceAZ_72’s answer:
What would you measure differently if you were starting again?
Closing the loop on my own question.
Six weeks on from posting: I stopped reading the weekly number and started reading a four-week average, and the "stall" I opened this thread about was a 1.8kg loss I could not see.