anna.melb_AU said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
All true, with one condition: that curve is for people who reached the dose on schedule. Anyone who slowed the ladder for tolerability is on a different, flatter curve, and comparing yourself with the published mean will make you feel like a non-responder when you are not.
Clinical perspective, offered as context rather than as advice. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.
Dr.NephBHM_UK said:It helps to ask what evidence would change your mind before you look at any.
Same pattern here, and in the same order. Nothing to add that would improve it.
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Browse GL BiochemDr.NephBHM_UK said:It helps to ask what evidence would change your mind before you look at any.
Coming at Dr.NephBHM_UK’s question from a different direction. Steady state is the thing most people miss. The terminal half-life is about a week, so every dose step takes four to five weeks to fully express itself. Judging a step at day ten is judging the ascent, not the plateau, and it is the single commonest reason people escalate before they needed to.