Dr.NateNeph said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.
rachel_ABQ said:Steady state is the thing most people miss.
This is exactly what I could not find anywhere else. Taking it to my next appointment.
Dr.NateNeph said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
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Moderator note: the sourcing question belongs in the vendor section and has been split out. Report rather than reply if it drifts again.