Adding the clinical framing, because it changes how the question reads. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.
From the other side of the consultation, briefly. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
andrew_nyc said:There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
Mine went the same way, slower.
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Shop Reference Standardsandrew_nyc said:There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
Coming at andrew_nyc’s question from a different direction. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.