anders_CPH said:The dose-response is real but shallow at the top.
Agreed, with the caveat that HbA1c is unreliable in anaemia, haemoglobinopathies and recent blood loss, all of which are commoner than people assume. If it disagrees with fasting glucose or a CGM, that is worth chasing.
anders_CPH said:The dose-response is real but shallow at the top.
Thank you for spelling out the reasoning rather than just the conclusion.
Adding the clinical framing, because it changes how the question reads. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.
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Browse GL BiochemDr.MetabolicMD said:The distinction that resolves most of these threads is between what is true on average and what is true for one person.
Same pattern here, and in the same order.
Dr.MetabolicMD said:The distinction that resolves most of these threads is between what is true on average and what is true for one person.
There is a second half to this that has not been said yet. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.