VendorMark said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.
Dr.MetabolicMD said:The pharmacokinetics explain nearly every practical question asked here.
Genuinely useful, thank you. I had the facts and not the framework.
VendorMark said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.
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Browse GL BiochemOne concrete data point for the thread. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.