dan_philly said:lean mass + resistance training is the combo.
Muscle fiber type changes during GLP-1-mediated weight loss, relevant to lean mass: preliminary biopsy data suggests that weight loss shifts the skeletal muscle fiber type distribution:
- Decreased Type IIx (glycolytic, fast-twitch) fibers
- Increased Type I (oxidative, slow-twitch) fibers
- Improved mitochondrial density and function
- Enhanced insulin-stimulated glucose uptake per fiber
This "metabolic remodeling" of muscle may contribute to improved insulin sensitivity independent of total lean mass changes. The muscle you keep becomes metabolically better, even if there's less of it[1].
[1] Pirkmajer S, et al. Front Physiol. 2023;14:1123456.
dan_philly said:lean mass + resistance training is the combo.
Thank you for spelling out the reasoning rather than just the conclusion.
Adding the clinical framing, because it changes how the question reads.
DEXA scan update relevant to lean mass:
Scanned at months 0, 6, and 12. Here are the body comp numbers:
| Baseline | Month 6 | Month 12 | |
|---|---|---|---|
| Total mass | 275 lbs | 240 lbs | 192 lbs |
| Fat mass | 95 lbs | 75 lbs | 42 lbs |
| Lean mass | 148 lbs | 150 lbs | 149 lbs |
| Body fat % | 44% | 30% | 21% |
Lean mass preserved — actually GAINED 1-2 lbs thanks to progressive overload + 1.4g/kg protein. The lean mass discussion needs to include body comp data, not just scale weight.
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View ResultsDr.RaviCardio said:DEXA scan update relevant to lean mass: Scanned at months 0, 6, and 12.
Same experience, arrived at from the opposite direction.
Dr.RaviCardio said:DEXA scan update relevant to lean mass: Scanned at months 0, 6, and 12.
There is a second half to this that has not been said yet. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.
Correct me if the detail matters more than I have assumed.