SarahChen_PharmD said:Body composition tracking via bioimpedance on lean mass (InBody scan every 3 months): Metric Baseline Month 3 Month 6 Month 9 Skeletal Muscle (lbs) 69…
Adding a me-too, because a thread of one person's experience is not much use.
quinn_sf said:lean mass + resistance training is the combo.
Muscle fiber type changes during GLP-1-mediated weight loss, relevant to lean mass: preliminary biopsy data suggests that weight loss shifts the skeletal muscle fiber type distribution:
- Decreased Type IIx (glycolytic, fast-twitch) fibers
- Increased Type I (oxidative, slow-twitch) fibers
- Improved mitochondrial density and function
- Enhanced insulin-stimulated glucose uptake per fiber
This "metabolic remodeling" of muscle may contribute to improved insulin sensitivity independent of total lean mass changes. The muscle you keep becomes metabolically better, even if there's less of it[1].
[1] Pirkmajer S, et al. Front Physiol. 2023;14:1123456.
quinn_sf said:lean mass + resistance training is the combo.
DEXA scan update relevant to lean mass:
Scanned at months 0, 6, and 12. Here are the body comp numbers:
| Baseline | Month 6 | Month 12 | |
|---|---|---|---|
| Total mass | 250 lbs | 210 lbs | 197 lbs |
| Fat mass | 100 lbs | 70 lbs | 47 lbs |
| Lean mass | 153 lbs | 149 lbs | 154 lbs |
| Body fat % | 43% | 35% | 21% |
Lean mass preserved — actually GAINED 1-2 lbs thanks to progressive overload + 1.6g/kg protein. The lean mass discussion needs to include body comp data, not just scale weight.
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Shop Reference Standardsquinn_sf said:lean mass + resistance training is the combo.
Saving this. It is the first explanation that did not require me to already understand it. Taking it to my next appointment.
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