Dr.SleepRoch said:The mental-health dimension is under-measured in the trial literature and the reports here are consistent enough to take seriously.
Agreed, and for anyone with an eating-disorder history this needs a clinician in the loop rather than a forum. The same drug can be therapeutic in binge-eating disorder and actively harmful in a restrictive disorder.
amsterdam_pete said:True, and anyone with reduced kidney function needs that target set by a clinician rather than a forum.
Thank you — that is the clearest version of this I have read, and I have read a lot of them. Printing the relevant bit and taking it with me.
Dr.SleepRoch said:The mental-health dimension is under-measured in the trial literature and the reports here are consistent enough to take seriously.
Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I would be careful about how confidently the flatness reports get attributed. Rapid weight loss, a large deficit and disrupted sleep produce low mood on their own, and separating that from a drug effect is genuinely hard.
I would rather be corrected than agreed with, if it comes to it.
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View ResultsOne concrete data point for the thread. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.