PedsEndoPhilly said:Bone density monitoring on lean mass: DEXA bone density at baseline and month 12.
Sharing my comprehensive lab data relevant to lean mass:
| Biomarker | Baseline | Month 3 | Month 6 | Month 9 |
|---|---|---|---|---|
| Weight (lbs) | 281 | 256 | 221 | 211 |
| A1C (%) | 7.6 | 6.1 | 6.2 | 5.3 |
| hsCRP (mg/L) | 6.0 | 5.0 | 2.5 | 0.7 |
| Triglycerides | 241 | 181 | 141 | 101 |
Protocol: Tirzepatide 10mg/wk, resistance training 5x/week, protein 1.5g/kg/day.
The improvements in lean mass are clearly reflected in these numbers. The inflammatory marker reduction (hsCRP) is particularly striking.
mike_mealprep said:Right, and protein targets should be set on a reference weight rather than current weight.
Thank you for spelling out the reasoning rather than just the conclusion. Adding it to my notes with a link back to this thread.
PedsEndoPhilly said:Bone density monitoring on lean mass: DEXA bone density at baseline and month 12.
Physical therapist weighing in on lean mass. I work with bariatric and metabolic patients daily.
The resistance training evidence is critical here:
The Lundgren 2024 JAMA paper[1] showed that structured resistance training preserved 73% more lean mass in GLP-1 patients vs medication alone. When discussing lean mass, we MUST include the exercise component.
My minimum prescription: 3x/week compound movements (squat, deadlift, press, row), progressive overload, 7-10K steps/day, and 1.2-1.6g protein/kg/day.
[1] Lundgren JR, et al. JAMA. 2024;331(1):38-48.
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View ResultsPeptideSynthNJ said:I lifted three times a week throughout and still lost lean mass.
Body composition tracking via bioimpedance on lean mass (InBody scan every 3 months):
| Metric | Baseline | Month 3 | Month 6 | Month 9 |
|---|---|---|---|---|
| Skeletal Muscle (lbs) | 69 | 67 | 68 | 71 |
| Body Fat (lbs) | 96 | 75 | 53 | 41 |
| Body Fat % | 39% | 32% | 26% | 21% |
| Visceral Fat (cm²) | 146 | 111 | 81 | 56 |
Note: skeletal muscle mass dipped initially then recovered with consistent resistance training + high protein. The visceral fat reduction is where the metabolic magic happens.