anna.melb_AU said:The GIP arm is doing real work rather than padding the label.
Agreed on the mechanism, with the caveat that the head-to-head used semaglutide 1mg, not 2.4mg. It is still the best direct evidence available, but it is not the comparison most people think they are citing.
lori_vegas said:Agreed on adaptation, with a caveat: adaptation applies to gastric emptying and not to everything.
This answered a question I did not know how to ask.
anna.melb_AU said:The GIP arm is doing real work rather than padding the label.
Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. The "tirzepatide is simply better" summary irritates me. It is better on mean weight loss, and the cardiovascular outcome evidence is far thinner than semaglutide's. If the reason for treating is cardiovascular risk rather than weight, the evidence base points the other way.
Correct me if the detail matters more than I have assumed.
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