Dr.EM_Chicago said:Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…
That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
SurmountFan_IN said:Agreed, and site choice does not change absorption for the weekly agents, so rotating costs nothing pharmacologically.
Thank you for spelling out the reasoning rather than just the conclusion.
Dr.EM_Chicago said:Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…
Pushing back on Dr.EM_Chicago here. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.
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Browse GL BiochemOne concrete data point for the thread. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.
Happy to go further on any of that.
Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Carry on.