Dr.PeteFamMed said:COA red flags for certificates of analysis — here's what to look for when reviewing a Certificate of Analysis: No HPLC data: If there's no…
My vendor review relevant to certificates of analysis: ordered 6 times from my current compounder. Consistency has been excellent.
Shipping: 3-day with temperature monitor
Packaging: Professional, discreet, proper labeling with lot/batch numbers
Purity: 99.7% average across orders (Janoshik verified)
Customer service: Responsive within 1 hours
Price: $151/month for semaglutide 1.7mg equivalent
B12Beth said:Agreed, and mass spec answers a question purity does not: identity.
This is exactly what I could not find anywhere else. Printing the relevant bit and taking it with me.
Dr.PeteFamMed said:COA red flags for certificates of analysis — here's what to look for when reviewing a Certificate of Analysis: No HPLC data: If there's no…
Vendor quality matters when discussing certificates of analysis. I've tested my last 4 batches through Janoshik and purity has ranged from 99.7% to 100.1%. Consistency is key.
For anyone new: always request the COA, and consider independent verification. The $300 for a Janoshik test is worth the peace of mind.
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View ResultsSarahChen_PharmD said:Two reports on the same product from two laboratories, four percentage points apart, and no method stated on either.
Mass spectrometry confirmation for certificates of analysis: beyond HPLC purity, mass spec tells you the molecule's exact molecular weight. This confirms identity — not just purity.
Why this matters: HPLC can show you a "pure" compound, but if it's pure of the WRONG compound, purity is meaningless. Mass spec at m/z 4113.58 Da confirms it's actually semaglutide. My Janoshik report includes both HPLC and mass spec.
If your testing provider only offers HPLC, consider upgrading to include mass spec for at least your first batch from a new vendor.
Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. No action needed from anybody.